降冰片烯
轴手性
钯
平面的
对映选择合成
二茂铁
芳基
平面手性
手性(物理)
化学
催化作用
组合化学
立体化学
有机化学
物理
共聚物
手征异常
计算机科学
物理化学
电化学
费米子
计算机图形学(图像)
聚合物
Nambu–Jona Lasinio模型
烷基
电极
量子力学
作者
Jinxiang Ye,Lisha Li,Yong You,Chengkang Jiao,Zhaolei Cui,Yabin Zhang,Shihu Jia,Hengjiang Cong,Shanshan Liu,Hong-Gang Cheng,Qianghui Zhou
出处
期刊:JACS Au
[American Chemical Society]
日期:2023-01-19
卷期号:3 (2): 384-390
被引量:3
标识
DOI:10.1021/jacsau.2c00630
摘要
The preparation of ferrocenes with both axial and planar chiralities poses a considerable challenge. Herein, we report a strategy for the construction of both axial and planar chiralities in a ferrocene system via palladium/chiral norbornene (Pd/NBE*) cooperative catalysis. In this domino reaction, the first established axial chirality is dictated by Pd/NBE* cooperative catalysis, while the latter planar chirality is controlled by the preinstalled axial chirality through a unique axial-to-planar diastereoinduction process. This method exploits readily available ortho-ferrocene-tethered aryl iodides (16 examples) and the bulky 2,6-disubstituted aryl bromides (14 examples) as the starting materials. Five- to seven-membered benzo-fused ferrocenes with both axial and planar chiralities (32 examples) are obtained in one step with constantly high enantioselectivities (>99% e.e.) and diastereoselectivities (>19:1 d.r.).
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