化学
双功能
对映选择合成
产量(工程)
烯烃纤维
催化作用
组合化学
形式综合
联轴节(管道)
醌
有机化学
立体化学
机械工程
工程类
冶金
材料科学
作者
Sijing Wang,Jia Yang,Hongkun Zeng,Yuqiao Zhou,Fei Wang,Xiaoming Feng,Shujuan Dong
标识
DOI:10.1021/acs.orglett.3c02885
摘要
A highly enantioselective formal coupling of β-ketoesters with quinones was accomplished by a chiral bifunctional N-heterocyclic olefin organocatalyst. With as low as 1 mol % catalyst loading, a number of enantioenriched quinone derivatives were afforded in good yields with high enantioselectivities and regioselectivities (up to 96% yield, 98% ee, and 19:1 rr). Gram-scale synthesis and the high inhibitory effect of several products on the viability of cancer cells demonstrate the potential utility of the current method.
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