瓜尔胶
姜黄素
聚乙烯醇
生物相容性
口服
药物输送
药理学
壳聚糖
化学
药品
体内
溃疡性结肠炎
结肠炎
控制释放
医学
生物化学
免疫学
有机化学
病理
疾病
生物技术
生物
作者
Yan Hu,Shangwen Zhang,Zhijie Wen,Hudie Fu,Jie Hu,Xuexin Ye,Li Kang,Xiaojun Li,Xinzhou Yang
标识
DOI:10.1016/j.ijbiomac.2022.09.050
摘要
Anti-inflammatory drugs for ulcerative colitis (UC) treatment should specifically penetrate and accumulate in the colon tissue. Herein, a multi-bioresponsive anti-inflammatory drug (curcumin, CUR)-loaded heterogeneous double-membrane microgels ([email protected]) for oral administration was fabricated in this study, in which the inner core was derived from polyvinyl alcohol (PVA) and guar gum (GG) and the outer gel was decoration with alginate and chitosan by polyelectrolyte interactions. The structure and morphology of microgels were characterized. In vitro, the formulation exhibited good bio-responses at different pH conditions and sustained-release properties in simulated colon fluid with a drug-release rate of 84.6 % over 34 h. With the assistance of the outlayer gels, the microgels effectively delayed the premature drug release of CUR in the upper gastrointestinal tract. In vivo studies revealed that [email protected] specifically accumulated in the colon tissue for 24 h, which suggest that the interlayer gels were apt to reach colon lesion. As expected, the oral administration of microgels remarkably alleviated the symptoms of UC and protected the colon tissue in DSS-induced UC mice. The above results indicated that these facilely fabricated microgels which exhibited excellent biocompatibility and multi-bioresponsive drug release, had an apparent effect on the treatment of UC, which represents a promising drug delivery strategy for CUR in a clinical application.
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