Pharmacokinetic study of ellagic acid and gallic acid of Punica granatum L.husk extract in rats

Objective To study the pharmacokinetic character of ellagic acid and gallic acid of pomegranate peel extract in rats. Methods After the rats were administered by pomegranate peel extract through ig, HPLC was used to determine the concentration of ellagic acid and gallic acid in blood plasma at different times, pharmacokinetic software Win Nonlin 5.2 was used to process concentration-time date. Results Ellagic acid and gallic acid were shown to be two room distribution model in rats, the main pharmacokinetic parameters of ellagic acid and gallic acid: T1/2(ka)=0.150, 0.779 h,T1/2α=0.570, 0.856 h, T1/2β=6.73, 5.59 h, Tmax=0.50, 1.38 h, Cmax=7.29, 7.15 μg/m L, α=1.21, 0.81 h-1, β=0.103, 0.124 h-1,Ka= 0.462, 0.889 h-1. Conclusion It indicates that the pharmacokinetic profile of ellagic acid and gallic acid are rapid absorption and distribution after oral administration pomegranate peel extraction, peak time is short, the absorption of gallic acid is greater than ellagic acid in pomegranate peel.