The plasmatic fibrinogen and essential hypertension(EH) associated with cardiovascular risk factors:an correlation study

Objective To explore the altered plasma fibrinogen(FIB)in patients with essential hypertension(EH) associated with different cardiovascular risk factors.Methods Between 1995 and 2006,a total of 1300 EH patients registered in Department of Cardiology,The First Affiliated Hospital of Fujian Medical University were divided into four groups:simple EH group(n=196),EH with one cardiovascular risk factor(EH+1) group(n=442),EH with two cardiovascular risk factors(EH+2) group(n=433) and EH with three or more cardiovascular risk factors(EH+≥3) group(n=229) according to the cardiovascular risk factors and two groups:EH with metabolic syndrome(EH+MS)group(n=496) and EH without MS(EH+nonMS) group(n=804) according to combination with MS or not.Results The plasmatic FIB level in EH group was significantly lower than that in other groups with cardiovascular risk factors [(3.17±0.89)g/L vs(3.37±0.93)g/L,(3.48±0.96)g/L and(3.84±1.13)g/L,P0.05].Notably,the FIB level in EH+≥3 group was remarkably higher as compared with EH+1 or EH+2 group(P0.05).The plasma FIB level in EH+MS group was significantly elevated than that in EH+nonMS group [(3.59±1.01)g/L vs(3.38±0.98)g/L,P0.01].There was no statistical difference in the plasmatic FIB level among grade 1,grade 2 and grade 3 EH patients after adjusting other influential factors.Furthermore,no difference was found in the FIB level across grade 1,grade 2 and grade 3 EH groups through analyisis of 196 simple EH patients after adjusting other influential factors.Conclusion The plasma FIB level was not significantly correlated with blood pressure but closely with EH associated cardiovascular risk factors.