[Objective]To investigate the related factors affecting the operative effect on discogenic low back pain.[Methods]A retrospective analysis was made on 145 patients with discogenic low back pain who underwent operation and had complete follow-up data from March 2004 to June 2009.The operative effect was assessed according to Oswestry Disability Index(ODI).Firstly,single factor analysis was used in 7 clinical variables which might affect the effect of the surgery,including age,course of disease,high-intensity zone(HIZ),Modic changes,discography pressure,sensitive degree to discoblock,degree of lumbar disc degeneration.Then,multivariate logistic regression analysis was applied to the indexes with statistical significance.[Results]Single factor analysis showed that age,course of disease,high-intensity zone(HIZ) were not significantly correlated with operative effect(P﹥0.05).While Modic changes,discography pressure,sensitive degree to discoblock,degree of lumbar disc degeneration were significantly correlated with operative effect(P0.05).Multivariate logistic regression analysis showed that discography pressure and sensitive degree to discoblock were two independent risk factors influencing the operative effect.The degree of disc degeneration was the protective factor.[Conclusion]Discography pressure and sensitive degree to discoblock are two independent risk factors of the surgery effect in discogenic low back pain.Of which,discography pressure is the most important controllable factor.The degree of disc degeneration is the protective factor.