Expression of Hugl-1 and aPKC in serous epithelial ovarian cancer

Objective To study the expression and significance of Hugl-1 and apical protein kinasec(aPKC)in serous epithelial ovarian cancer.Methods The expressions of Hugl-1 and aPKC protein in 25 normal epithelial ovarian tissues,31 benign,41 borderline and 79 malignant serous ovarian cancer tissues were detected with the method of immunohistochemistry.The relationship between the respective expression of Hugl-1 and aPKC in serous epithelial ovarian cancer and various clinicopathologic factors had been analyzed.Results Positive expressions of Hugl-1 in serous ovarian cancers,normal,benign and borderline were 12.7%、48%、58%、41.5% respectively.The expressions of Hugl-1 in serous ovarian cancers were significantly lower than those in normal,benign and borderline tissues(P0.001).The expressions of aPKC in serous ovarian cancers normal,benign and borderline were 19%,0,0,0 respectively.The expressions of aPKC in serous ovarian cancers were significantly higher than those in other groups(P0.001).The expressions of Hugl-1 and aPKC were respectively related to pathological grade,clinical stage and Lymph node metastasis.There wasn't correlation between the expressions of the two proteins in serous ovarian cancer(P0.05).Conclusion The two proteins may be involved in the carcinogenesis of serous ovarian cancer.