Research progress in the treatment of osteoporosis with stem cells transplantation

With the population life extending and the aging society, the number of the patients with osteoporosis is increasing in China. By now, the treatment of primary osteoporosis generally is medicines treatment for disorder of bone formation and resorption, and the therapy with mesenchymal stem cells (MSCs) for osteoporosis has not been developed. The senescence of MSCs is one of the pathogenesis of primary osteoporosis. Researches demonstrate that MSCs aging leads to the impaired osteogenic differentiation, increased adipogenic differentiation, decreasing BMD. And all of these finally result in bone loss, abnormal bone microstructure, and osteoporosis. Investigations of stem cellular transplantation show increase of BMD, biomechanical, and osteogenesis. It supplies us with a new strategy and method for the treatment of osteoporosis. Stem cells transplantation would become a effective and safe treatment of osteoporosis with the development of applications, technology and biomaterials.