Objective To understand anxiety and depression status among female college students, to explore the relationship between anxiety, depression and personality and to provide reference for the intervention. Methods A total of 1334 female college students were anonymously investigated by using SAS, CES-D and EPQ. Results The prevalence rates of anxiety and depression was 6.4% and 22.7% respectively, and the rate of combined anxiety and depression was 5.5%. Among the students coming from the normal universities or the science and technology universities, N scores, P scores and E scores were associated with anxiety; poor school achievements, low education level of mother, N scores, P scores and E scores were associated with depression. Conclusion Anxiety and depression syndromes are common among female college students. Preventive intervention should focus on the related risk factors to promote their mental health.