内皮蛋白C受体
T细胞受体
CD1D公司
细胞生物学
抗原
主要组织相容性复合体
生物
T细胞
克隆(Java方法)
受体
免疫学
分子生物学
免疫系统
凝血酶
基因
生物化学
血小板
作者
Carrie R. Willcox,Vincent Pitard,Sonia Netzer,Lionel Couzi,Mahboob Salim,Tobias Silberzahn,Jean-François Moreau,Adrian Hayday,Benjamin E. Willcox,Julie Déchanet‐Merville
摘要
T cells bearing γδ T cell antigen receptors (TCRs) function in lymphoid stress surveillance. However, the contribution of γδ TCRs to such responses is unclear. Here we found that the TCR of a human V(γ)4V(δ)5 clone directly bound endothelial protein C receptor (EPCR), which allowed γδ T cells to recognize both endothelial cells targeted by cytomegalovirus and epithelial tumors. EPCR is a major histocompatibility complex-like molecule that binds lipids analogously to the antigen-presenting molecule CD1d. However, the V(γ)4V(δ)5 TCR bound EPCR independently of lipids, in an antibody-like way. Moreover, the recognition of target cells by γδ T cells required a multimolecular stress signature composed of EPCR and costimulatory ligand(s). Our results demonstrate how a γδ TCR mediates recognition of broadly stressed human cells by engaging a stress-regulated self antigen.
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