Regioselective Postsynthetic Modification of Phenylalanine Side Chains of Peptides Leading to Uncommon ortho‐Iodinated Analogues

A convenient and direct iodination of Phe residues in peptide sequences was observed upon treatment with IPy2BF4. The experimental conditions were optimized (see scheme) and the role of the peptidyl fragment to drive the formation of the elusive ortho-iodo isomer as the major product was investigated. Supporting information for this article is available on the WWW under http://www.wiley-vch.de/contents/jc_2002/2004/z52464_s.pdf or from the author. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.