糖尿病前期
医学
2型糖尿病
腰围
超重
队列
人口学
人体测量学
肥胖
人口
高甘油三酯血症
队列研究
优势比
内科学
糖尿病
老年学
环境卫生
内分泌学
甘油三酯
胆固醇
社会学
作者
Masoumeh Sadeghi,Mohammad Talaei,Ehsan Parvaresh Rizi,Minoo Dianatkhah,Shahram Oveisgharan,Nizal Sarrafzadegan
标识
DOI:10.1111/1753-0407.12236
摘要
Abstract Background This study aimed to identify determinants of new onset type‐2 diabetes ( T2D ) and prediabetes in a region with high rate of T2D but scarcity of evidence. Methods Participants free of T2D were identified in a population‐based study of adults older than 35 years living in the rural and urban areas of three districts in I ran in 2001 and were re‐examined after 7 years. Biochemical measurements, anthropometric data, blood pressure, smoking status and dietary intake were determined at both measurement points through identical protocols and procedures. Data analysis was done using multivariate ordered logistic regressions. Results Incidence rate of prediabetes and T2D was 32.3 (95% CI , 29.7–35.1) and 18.9 (17.1–20.9) per 1000 person‐year, respectively. Odds of progression to prediabetes and T2D were increased with ageing, living in rural area ( OR = 1.28), unhealthy diet ( OR = 1.32), overweight ( OR = 1.45), obesity ( OR = 1.97), waist gain ( OR = 1.37), high waist‐to‐hip ratio ( OR = 1.35), hypertension ( OR = 1.35), and hypertriglyceridemia ( OR = 1.50); but reduced with higher education ( OR = 0.76) and weight loss ( OR = 0.67) in the adjusted models. In those with prediabetes at baseline, parental history of T2D ( OR = 2.26), obesity ( OR = 2.59), high waist circumference ( OR = 2.03), and hypertriglyceridemia ( OR = 1.94) were associated with developing T2D . No factor was found to be associated with regression from prediabetes to normoglycemia in adjusted models. Conclusions Current data endorses proposed statistical projections for the future trend of diabetes, and highlights the potential role of obesity specifically visceral type.
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