透明质酸
透明质酸酶
硫黄
硫酸
粘附
细胞粘附
生物化学
材料科学
聚合物
体内
细胞
碳水化合物
酶
生物物理学
化学
生物
无机化学
解剖
复合材料
冶金
生物技术
作者
Yang Yu,Shijie Zhu,Yachen Hou,Jingan Li,Shaokang Guan
标识
DOI:10.1021/acsami.0c15729
摘要
Hyaluronic acid (HA) is recognized as a functional carbohydrate polymer applied for the surface modification of cardiovascular implanted materials due to its molecular weight (MW) dependent cellular regulation. However, due to the enzyme digestion of hyaluronidase on HA in vivo, the stability of HA MW needs to be further improved. It has been reported that the stability of HA MW can be improved by sulfonation. In this study, sulfonated hyaluronic acids (S-HA) with sulfur content of 2.06, 3.69, 7.10, 8.98, and 9.71 were prepared through different sulfuric acid treatment procedures. Cell tests showed that S-HA with higher sulfur content played a significant role in promoting the proliferation and migration of endothelial cells and regulating smooth muscle cells to the physiological phenotype. In addition, it was also proved to inhibit the inflammatory macrophages adhesion/activation. Our data indicates that S-HA may be a better carbohydrate polymer for potential application of cardiovascular biomaterials.
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