Pharmacokinetics of doxycycline and tiamulin in calves body after using the injection form of Tiacycline®

Pharmacokinetics of tiamulin and doxycicline in the blood plasma of calves was investigated following single intramuscular administration of Tiacyclin solution for injection as a part of the preclinical studies. Tiacyclin ® solution for injection, was administered to 6 calves once intramuscularly in the neck area at the dose of 1 ml/12,5 kg. In 0; 0,5; 1,0; 1,5; 3,0; 6,0; 12,0; 18,0; 24,0; 48,0 and 96,0 hours following Tiacyclin administration blood samples were collected and tiamulin and doxycicline concentrations in blood plasma were analyzed by high performance liquid chromatography using a fluorescent detection. The pharmacokinetic profile of tiamulin and doxycicline in blood plasma of calves was established.