[A systematic review of the economic burden of influenza in China].

Objectives: To understand the status of studies about influenza economic burden in mainland China and summarize their major results. Methods: The words of influenza, flu, cost, economic, burden, effectiveness, benefit, utility, China, and Chinese, were used as search keywords. Journal papers published during 2000-2018 were searched from Chinese electronic databases (CNKI and Wanfang) and English electronic databases (PubMed, Web of science, EconLit and Cochrane Library). The language of literature was restricted to Chinese and English. A total of 23 effective documents were included, and the descriptive characteristics, research indexes and methods included in the literature were analyzed. The monetary unit used in this review is Chinese Yuan (CNY). Results: The 23 study sites were mainly in the relatively developed and populous regions. The total cost per capita of laboratory-confirmed influenza,of all age-group was reported in 6 literatures, and only 4 literatures reported it in out-patients (range: 768.0-999.9 CNY), Only one study reported this indicator in inpatients (9 832.0 CNY). One literature reported the total cost per capita of influenza-like illness,, which was 205.1 CNY. And one literature reported that the direct medical cost of inpatients per capita in children under 5 years of age was 6 072.0 CNY while two literature reported this index for the elderly over 60 years of age, ranging from 14 250.0 to 19 349.1 CNY. Four articles reported the economic burden of influenza in urban and rural areas, one of which showed that the related expenses of urban influenza inpatients accounted for 31% of the average annual income, while which for the rural flow was 113%. Conclusion: The average economic burden of lab-confirmed influenza case is higher than that of influenza-like illness, and there are differences in outpatient indirect expenses and inpatients direct medical expenses. The direct medical burden for the hospitalized 60-years-and-beyond influenza case group is heavier thar other age group. By region, the influenza associated individual economic burden in rural area is higher than that of urban area..目的： 了解中国流感经济负担研究现状并总结主要结果。 方法： 以流感、流行性感冒、成本、经济、负担、费用、效益、效用和效果，以及influenza、flu、cost、economic、burden、effectiveness、benefit、utility、China和Chinese为关键词，系统检索中国知网、万方数据知识服务平台、Pubmed、Web of science、EconLit和Cochrane Library等数据库中2000—2018年中国流感经济负担的经济学研究相关文献，语种限定为中文和英文，共纳入23篇有效文献，对纳入文献的基本信息、研究指标及方法进行分析，经济相关指标的单位均为元人民币。 结果： 23篇文献主要集中在经济发达、人口较多的地区，6篇文献报道了全年龄组流感确诊病例的总经济负担，其中，4篇报告了门诊病例人均总经济负担，其范围为768.0~999.9元，1篇报告了住院病例的该项指标（9 832.0元）；1篇文献报告了流感样病例人均门诊总经济负担，为205.1元。1篇文献报告了5岁以下儿童住院病例人均直接医疗费用为6 072.0元，而有2篇文献报告了60岁及以上老年人的此项指标，其范围为14 250.0~19 349.1元。4篇文献报告了城市和农村的流感经济负担，其中1篇显示，城市流感住院患者相关费用占年均收入的比例为31%，而农村为113%。 结论： 中国流感确诊病例平均经济负担高于流感样病例，其中门诊间接费用及住院直接医疗费用差异较大。流感住院病例中60岁及以上年龄组的直接医疗负担较重。农村地区流感导致个人经济负担高于城市地区。.