Synthesis and analgesic activity of novel L-amino acid based small molecule N-type calcium channel blockers

Objective To obtain small molecule compounds possessing analgesic activity.Methods Eight L-amino acid based small molecules were designed and synthesized and their analgesic activities were evaluated by the rat hot pat pain model.Results Synthesized target compounds by convenient method and the result of pharmacology indicated part of these compounds possessed analgesic activity.Conclusions The results show that compound 5d and 5f possess the better analgesic activity which can be a lead compound for the further modification.