Objective To evaluate the clinical therapeutic effect and safety of hemoperfusion in rescuing patients with severely poisoning Methods 34 cases with severity poison were saved with hemoperfusion combined with other drugs treatment Results after 37 times treatment with hemoperfusion, 32 cases among 34 patients with severe poisoning had been saved, the cure rate was 94 12%, that was higher than the non hemoperfusion group, the treatment time was shorter and had no serious adverse reaction and sequelae occurred in hemoperfusion group Conclusion the method of hemoperfusion in saving severity poison patients is effect and safety