Objective To explore the factors of schizophrenia patients appearing constipation after taking antipsychotic.Methods 182 patients were studied when they appeared constipation after taking antipsychotic.Results The rate of constipation was 42.86%, the sex,age,kind and dose of drug were closely related to constipation.Conclusion It is important to take preventive measures early and watch closely and deal with it in time when constipation appears.