Influence of tetrodotoxin on sodium channel and the possible mechanism of the analgesic effect

Tetrodotoxin(TTX) is a potent sodium channel blocker. It can affect the generation of action potentials of cell membranes by blocking sodium channel. Damaged tissues express a Tetrodotoxin resistant(TTX R) Na + current which provides a potential target for therapeutic intervention in a range of pain states. We summarize the influence of tetrodotoxin on sodium channel and the possible mechanism of the analgesic effect.