Objective:To study the thermal decomposition of chlorobenzylidine. Method and Results: TG
(thermogravimetry) and DSC ( differential scanning calorimetry) were used to study the decomposition kinetics of solid drug chlorobenzylidine, determine the thermal kinetic parameter energy of activation (E). IR, NMR, powder X -ray diffraction (PXRD) and HPLC were also used to study the thermal decomposition of the drug, determine the structure of principal decomposition products in thermal decomposition process. Conclusion: The method is simple and easy to do with reliable results.