对映体药物
芳基
催化作用
化学
方案(数学)
铜
氮气
简单(哲学)
配体(生物化学)
组合化学
计算机科学
有机化学
数学
对映选择合成
哲学
受体
数学分析
烷基
认识论
生物化学
作者
Bruce H. Lipshutz,Hideo Shimizu
标识
DOI:10.1002/anie.200353294
摘要
Are you looking for an operationally simple means of preparing enantio-enriched benzylic-like centers bearing nitrogen? Consider this new and convenient alternative to asymmetric hydrogenation: CuH when ligated by an enantiopure SEGPHOS ligand can catalytically reduce aryl ketimines at room temperature in high yields and even higher ee values (see scheme; TMDS=tetramethyldisiloxane). Supporting information for this article is available on the WWW under http://www.wiley-vch.de/contents/jc_2002/2004/z53294_s.pdf or from the author. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.
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