近紅外光驅動多功能奈米材料作為光熱治療及藥物遞送平台：中孔洞二氧化矽包覆四氧化三鐵－金核殼結構

Since the date that nanomaterial been developed, there’re numerous related explorations and application in biomedical field. Upon all kind of the nanomaterials, magnetic nanoparticles and gold nanomaterials are more extensively researched. Magnetic nanoparticles can be used in magnetic targeting, magnetic resonance imaging (MRI), etc., whereas gold nanomaterials can be applied in photothermal therapy because of the surface plasma resonance character of gold nanomaterials. Furthermore, the application of nanomaterials as anti-cancer drug carrier has been widely developed. For example, there’re many study about mesoporous silica nanomaterial, which can be used as drug carrier. Supposing that there’re stimuli-responsive caps attached on the mesoporous silica nanomaterial surface which can be the switch of the drug, we may attain the goal to control anti-cancer drug release. In addition, we may be able to use less amount of the drug to reach the effective cancer therapy. In this study, we take iron oxide coated gold nanoshell (Fe3O4@Au) as the core of the nanocarrier, which can be applied to magnetic targeting, MRI, and thermotherapy. Moreover, coating mesoporous silica shell on Fe3O4@Au core may render us to load doxorubicin (an anti-cancer drug) into the pores of mesoporous silica shell. At last, we use stimuli-responsive double stranded deoxyribonucleic acid (dsDNA) as the caps to cover the pore which loaded doxorubicin. Owing to the stimuli-responsive caps, we are able to use NIR laser light to trigger doxorubicin release, and achieve the purpose of controlling drug release.