DNA旋转酶
化学
抗菌活性
抗菌剂
克
立体化学
体外
效力
结构-活动关系
抗生素
化学合成
组合化学
大肠杆菌
细菌
生物化学
生物
遗传学
基因
作者
Tuan P. Tran,Edmund L. Ellsworth,Michael A. Stier,John M. Domagala,Hollis D. Showalter,Stephen J. Gracheck,Martin A. Shapiro,Themis E. Joannides,Rajeshwar Singh
标识
DOI:10.1016/j.bmcl.2004.06.063
摘要
A series of 3-hydroxyquinazoline-2,4-diones was synthesized and evaluated for antibacterial activity. This series represents a novel addition to the DNA gyrase inhibitor class of antibacterials. Appropriate substitutions onto the core template yielded compounds with excellent potency against E. coli gyrase and significant in vitro Gram-negative and Gram-positive antibacterial activity.
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