Latest Advances in Specific Inhibition of Tumor-Associated Carbonic Anhydrases

碳酸酐酶 背景(考古学) 化学 酶 医学 生物化学 生物 古生物学
作者
Claudiu Trandafir Supuran
出处
期刊:Future Medicinal Chemistry [Future Science Ltd]
卷期号:15 (1): 5-7 被引量:21
标识
DOI:10.4155/fmc-2022-0249
摘要

Future Medicinal ChemistryVol. 15, No. 1 EditorialLatest advances in specific inhibition of tumor-associated carbonic anhydrasesClaudiu T SupuranClaudiu T Supuran *Author for correspondence: E-mail Address: claudiu.supuran@unifi.ithttps://orcid.org/0000-0003-4262-0323Department of Neurofarba, Pharmaceutical & Nutraceutical Section, University of Florence, Via Ugo Schiff 6, Sesto Fiorentino, Florence, 50019, ItalySearch for more papers by this authorPublished Online:13 Jan 2023https://doi.org/10.4155/fmc-2022-0249AboutSectionsView ArticleView Full TextPDF/EPUB ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareShare onFacebookTwitterLinkedInRedditEmail View articleKeywords: anticancer theragnostic agentcarbonic anhydrase IX/XIIferroptosishypoxic tumorsinhibitorsReferences1. Aspatwar A, Tolvanen MEE, Barker H et al. Carbonic anhydrases in metazoan model organisms: molecules, mechanisms, and physiology. Physiol. Rev. 102, 1327–1383 (2022).Crossref, Medline, CAS, Google Scholar2. Supuran CT. Carbonic anhydrases: novel therapeutic applications for inhibitors and activators. Nature Rev. Drug Discov. 7, 168–181 (2008).Crossref, Medline, CAS, Google Scholar3. Kciuk M, Gielecińska A, Mujwar S et al. Targeting carbonic anhydrase IX and XII isoforms with small molecule inhibitors and monoclonal antibodies. J. Enzyme Inhib. Med. Chem. 37(1), 1278–1298 (2022).Crossref, Medline, CAS, Google Scholar4. Nocentini A, Angeli A, Carta F et al. Reconsidering anion inhibitors in the general context of drug design studies of modulators of activity of the classical enzyme carbonic anhydrase. J. Enzyme Inhib Med. Chem. 36, 561–580 (2021).Crossref, Medline, CAS, Google Scholar5. Kim D, Kim S, Park G, Choi H, Ryu JH. Spatiotemporal self-assembly of peptide amphiphiles by carbonic anhydrase IX- targeting induces cancer-lysosomal membrane disruption. JACS Au. 2(11), 2539–2547 (2022).Crossref, Medline, CAS, Google Scholar6. Supuran CT. Emerging role of carbonic anhydrase inhibitors. Clin. Sci. (Lond.) 135, 1233–1249 (2021).Crossref, Medline, CAS, Google Scholar7. Flaherty DP, Seleem MN, Supuran CT. Bacterial carbonic anhydrases: underexploited antibacterial therapeutic targets. Future Med. Chem. 13, 1619–1622 (2021).Link, Google Scholar8. De Luca V, Carginale V, Supuran CT, Capasso C. The Gram-negative bacterium Escherichia coli as a model for testing the effect of carbonic anhydrase inhibition on bacterial growth. J. Enzyme Inhib. Med. Chem. 37, 2092–2098 (2022).Crossref, Medline, Google Scholar9. Supuran CT. How many carbonic anhydrase inhibition mechanisms exist? J. Enzyme Inhib. Med. Chem. 31, 345–360 (2016).Crossref, Medline, CAS, Google Scholar10. Supuran CT. Carbonic anhydrase activators. Future Med. Chem. 10, 561–573 (2018).Link, CAS, Google Scholar11. Oehler S, Catalano M, Scapozza I et al. Affinity selections of DNA-encoded chemical libraries on carbonic anhydrase IX-expressing tumor cells reveal a dependence on ligand valence. Chemistry 27(35), 8985–8993 (2021).Crossref, Medline, CAS, Google Scholar12. Supuran CT. Carbonic anhydrase inhibitors: an update on experimental agents for the treatment and imaging of hypoxic tumors. Expert Opin. Investig Drugs 30, 1197–1208 (2021).Crossref, Medline, CAS, Google Scholar13. McDonald PC, Chafe SC, Supuran CT, Dedhar S. Cancer therapeutic targeting of hypoxia induced carbonic anhydrase IX: from bench to bedside. Cancers (Basel) 14, 3297 (2022).Crossref, Medline, CAS, Google Scholar14. Chafe SC, Vizeacoumar FS, Venkateswaran G et al. Genome-wide synthetic lethal screen unveils novel CAIX-NFS1/xCT axis as a targetable vulnerability in hypoxic solid tumors. Sci. Adv. 7, eabj0364 (2021).Crossref, Medline, CAS, Google Scholar15. McDonald PC, Chia S, Bedard PL et al. A phase 1 study of SLC-0111, a novel inhibitor of carbonic anhydrase IX, in patients with advanced solid tumors. Am. J. Clin. Oncol. 43, 484–490 (2020).Crossref, Medline, CAS, Google Scholar16. Millul J, Krudewig C, Zana A et al. Immunotherapy with immunocytokines and PD-1 blockade enhances the anticancer activity of small molecule-drug conjugates targeting carbonic anhydrase IX. Mol. Cancer Ther. 20(3), 512–522 (2021).Crossref, Medline, CAS, Google Scholar17. Liguori F, Carradori S, Ronca R et al. Benzenesulfonamides with different rigidity-conferring linkers as carbonic anhydrase inhibitors: an insight into the antiproliferative effect on glioblastoma, pancreatic, and breast cancer cells. J. Enzyme Inhib. Med. Chem. 37, 1857–1869 (2022).Crossref, Medline, CAS, Google Scholar18. Nerella SG, Singh P, Arifuddin M, Supuran CT. Anticancer carbonic anhydrase inhibitors: a patent and literature update 2018-2022. Expert Opin. Ther. Pat. 32, 833–847 (2022).Crossref, Medline, CAS, Google Scholar19. Kumar A, Siwach K, Supuran CT, Sharma PK. A decade of tail-approach based design of selective as well as potent tumor associated carbonic anhydrase inhibitors. Bioorg. Chem. 126, 105920 (2022).Crossref, Medline, CAS, Google Scholar20. Nannini G, De Luca V, D'Ambrosio C et al. A comparative study of carbonic anhydrase activity in lymphocytes from colorectal cancer tissues and adjacent healthy counterparts. J. Enzyme Inhib. Med. Chem. 37, 1651–1655 (2022).Crossref, Medline, CAS, Google ScholarFiguresReferencesRelatedDetails Vol. 15, No. 1 STAY CONNECTED Metrics Downloaded 47 times History Received 10 October 2022 Accepted 12 December 2022 Published online 13 January 2023 Published in print January 2023 Information© 2023 Newlands PressKeywordsanticancer theragnostic agentcarbonic anhydrase IX/XIIferroptosishypoxic tumorsinhibitorsFinancial & competing interests disclosureResearch from the author's laboratory was financed by the Italian Ministry for University and Research (MIUR), grants PRIN prot. 2017XYBP2R and FISR2019_04819 BacCAD. The author declares conflict of interest, being one of the discoverers of SLC-0111. The author has no other relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript apart from those disclosed.No writing assistance was utilized in the production of this manuscript.PDF download

科研通智能强力驱动
Strongly Powered by AbleSci AI
科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
刚刚
田様的应助被xxx采纳,获得10
刚刚
lina完成签到,获得积分10
刚刚
jiqihao完成签到,获得积分10
1秒前
husuhew完成签到,获得积分10
1秒前
学术雷锋的应助被袁琴采纳,获得10
1秒前
曲意风华发布了新的文献求助10
1秒前
1秒前
2秒前
风禾尽起完成签到 ,获得积分10
2秒前
ss完成签到,获得积分10
2秒前
情怀的应助被wyitong2024采纳,获得10
2秒前
yu发布了新的文献求助10
2秒前
初青酱完成签到,获得积分10
2秒前
改善完成签到,获得积分10
2秒前
完美世界的应助被special采纳,获得10
3秒前
阳光谷完成签到,获得积分10
3秒前
小马甲的应助被alexlpb采纳,获得10
3秒前
学术雷锋的应助被杨霖云采纳,获得10
3秒前
3秒前
4秒前
11完成签到 ,获得积分10
4秒前
ZZ完成签到 ,获得积分10
4秒前
2401完成签到,获得积分10
4秒前
邱回完成签到,获得积分10
5秒前
YSSS发布了新的文献求助10
5秒前
玄轩完成签到,获得积分10
5秒前
vicluwang完成签到,获得积分10
5秒前
FashionBoy的应助被端庄书雁采纳,获得10
5秒前
6秒前
YuJiao完成签到,获得积分10
6秒前
6秒前
6秒前
123发布了新的文献求助10
6秒前
学术雷锋的应助被科研狼采纳,获得10
7秒前
秀丽雁芙完成签到 ,获得积分10
7秒前
思源的应助被跳跃彩虹采纳,获得10
7秒前
7秒前
8秒前
8秒前
高分求助中
(应助此贴封号)【重要!!请各用户(尤其是新用户)详细阅读】【科研通的精品贴汇总】 10000
Energie-Contracting 1500
Spec 401: Standards for Jet Fuel Facility and Equipment Commissioning and Flushing at Airports, 2026.1 (Original Issue) 1000
Spec 103: Standard for Jet Fuel Quality Control at Airports, Revision 2026.1 1000
Mathematical models in hydrology 1000
Klimaschutzrecht durch den Energiesektor im Mehrebenensystem – Ein Rechtsvergleich 1000
Erzählte Gnade 500
热门求助领域 (近24小时)
化学 材料科学 医学 生物 纳米技术 计算机科学 工程类 有机化学 化学工程 生物化学 物理 复合材料 内科学 催化作用 光电子学 人工智能 细胞生物学 无机化学 物理化学 数学
热门帖子
关注 科研通微信公众号,转发送积分 8087665
求助须知:如何正确求助?哪些是违规求助? 9500972
关于积分的说明 21423477
捐赠科研通 7659238
什么是DOI,文献DOI怎么找? 3403791
关于科研通互助平台的介绍 2532446
邀请新用户注册赠送积分活动 2442166