对映选择合成
皮克特-斯宾格勒反应
有机催化
生化工程
组合化学
催化作用
化学
有机化学
工程类
标识
DOI:10.1002/slct.202203368
摘要
Abstract The Pictet‐Spengler reaction is a century old technique for the construction of aza‐cycles, which has been extensively researched through organocatalytic methods over the past two decades. The asymmetric variant of this reaction has gained considerable attention because the enantioenriched poly heterocycles accessed through the process are prevalent in natural products and bioactive moleculesPrime focus of this review is the systematic and chronological assembly of enantioselective P−S reaction catalyzed by different types of organocatalysts. Mechanistic approaches to rationalize the asymmetric induction on the products are an additional flavor of the article. Importance of this conventional reaction has been justified by the synthesis of different biologically and naturally relevant compounds which have been highlighted in this review as well.
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