医学
体细胞
生殖系
种系突变
基因
遗传学
癌症研究
内科学
免疫学
突变
生物
作者
Ruaa Al‐Qazazi,Isaac Emon,François Potus,Ashley Martin,Patrícia Lima,Caitlyn Vlasschaert,Benjamin P. Ott,Kuang‐Hueih Chen,Danchen Wu,Asish Dasgupta,Curtis Noordhof,Lindsay Jefferson,Marco M. Buttigieg,Amy J. M. McNaughton,Charles C.T. Hindmarch,Alexander G. Bick,William C. Nichols,Wendy K. Chung,Paul M. Hassoun,Rachel L. Damico
标识
DOI:10.1093/eurheartj/ehaf611
摘要
Germline DNMT3A variants and somatic variants of DNMT3A and CHIP genes increase the risk of PAH, including APAH-CTD, promote inflammation, and constitute potential biomarkers and therapeutic targets.
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