Three Previously Undescribed Compounds Isolated From the Leaves of Syzygium antisepticum With Their α‐Glucosidase and Nitric Oxide Inhibitory Activity

Three previously undescribed compounds, 2α,3β,20α,23-tetrahydroxy-nor-30-urs-12-en-28-oic acid 28-O-β-d-glucopyranoside (1), 2α,3β,6β,23-tetrahydroxyoleana-11,13(18)-dien-28-oic acid (2), and 4,6-dihydroxy-3-methyl-2-O-β-d-glucopyranosylbenzophenone (3), together with 11 known compounds (4-14) are isolated from the leaves of Syzygium antisepticum. The isolated compounds are characterized via HR-ESI-MS and NMR spectra. Compounds 1, 2, 6, and 7 exhibited significant inhibition of NO production in lipopolysaccharide (LPS)-activated murine macrophage RAW264.7 cells with IC₅₀ values of 16.3, 14.9, 25.5, and 24.7 µM, respectively. In addition, compounds 9-12 displayed the most potential α-glucosidase with IC₅₀ values ranging from 23.6 to 162.0 µM.