同种免疫
炎症
医学
免疫学
器官移植
移植
抗体
外科
作者
Adriana Franco-Acevedo,Christopher L. Pathoulas,Patrick A. Murphy,Nicole M. Valenzuela
出处
期刊:Journal of Immunology
[The American Association of Immunologists]
日期:2023-11-01
卷期号:211 (9): 1276-1285
标识
DOI:10.4049/jimmunol.2300363
摘要
Ab-mediated rejection of organ transplants remains a stubborn, frequent problem affecting patient quality of life, graft function, and grant survival, and for which few efficacious therapies currently exist. Although the field has gained considerable knowledge over the last two decades on how anti-HLA Abs cause acute tissue injury and promote inflammation, there has been a gap in linking these effects with the chronic inflammation, vascular remodeling, and persistent alloimmunity that leads to deterioration of graft function over the long term. This review will discuss new data emerging over the last 5 y that provide clues into how ongoing Ab-endothelial cell interactions may shape vascular fate and propagate alloimmunity in organ transplants.
科研通智能强力驱动
Strongly Powered by AbleSci AI