类有机物
诱导多能干细胞
干细胞
毛囊
人体皮肤
移植
生物
医学
神经科学
细胞生物学
胚胎干细胞
外科
遗传学
基因
生物化学
作者
Aaron Gabriel W. Sandoval,Kelly Y. Gim,Jennifer T. Huang,Karl R. Koehler
标识
DOI:10.1016/j.jid.2023.07.017
摘要
Pluripotent stem cells have the potential to become any cell type, and recently, they have been used to create organoids that can recapitulate several pertinent features of human organs. Skin organoids have been developed that possess many of the crucial accessory organs, including hair follicles, sebaceous glands, nerves, fat, and melanocytes. These skin organoids present the opportunity to study skin development and disease as well as perform screens to identify new drug candidates. In the future, skin organoids might augment clinical practice by serving as source material for transplantation to treat wounds or other conditions. Nevertheless, several limitations, such as the lengthy differentiation protocol, which can result in heterogeneous products, must first be addressed before the full potential of skin organoids can be realized. The purpose of this article is to provide a broad overview of skin organoids so that a broader audience can become familiar with this technology, which has important implications for dermatologic research and medicine.
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