There is no difference in the efficacy of anterior cruciate ligament reconstruction using autograft combined with or without ligament augmentation: a systematic review and meta‐analysis

Abstract Purpose This study aims to determine the efficacy of anterior cruciate ligament reconstruction (ACLR) using autograft combined with or without ligament augmentation. Methods A computerized search of the databases was conducted, including PubMed, Web of Science, Embase, Scopus and the Cochrane Library. Only prospective or retrospective comparative studies with a minimum 2‐year follow‐up were considered for inclusion. Two independent reviewers performed data extraction and methodological quality assessment. A Mantel–Haenszel analysis was used for the pooling of results. Sensitivity analysis was performed to maintain the stability of results. The egger test was applied to assess the publication bias. Results Fourteen studies were included. The total cohort was 1353 patients (non‐augmented group: 763 patients; augmented group: 590 patients). There were three Randomized Controlled Trials (RCTs, Level I), six retrospective comparative studies (Level III) and five case–control studies (Level III). The follow‐up rate was ≥ 88% and the follow‐up periods were ≥ 24 months in all included studies. The augmented graft used to compare with autograft included the Ligament Augmentation Device (LAD), the Ligament Advanced Reinforcement System (LARS) artificial ligament, FiberTape, hamstring tendon allograft, degradable poly (urethane urea). No significant differences were observed between the augmented and non‐augmented groups regarding postoperative patient‐reported outcomes (PROs), including the International Knee Documentation Committee score, Lysholm score and Tegner score, knee laxity, including KT‐1000, side‐to‐side difference, Lachman test and pivot shift and rate of graft failure. Conclusions ACLR using autografts combined with ligament augmentation shows no advantages in PROs, knee laxity and graft failure rate compared with using autografts only. Level of evidence Level III. Trial registration The research protocol was registered at the PROSPERO database (CRD42022324784).