子宫肌瘤
PI3K/AKT/mTOR通路
内分泌干扰物
雌激素
平滑肌瘤
细胞生长
内分泌系统
内分泌学
生物
XBP1型
内科学
癌症研究
信号转导
细胞生物学
子宫
医学
基因
激素
遗传学
核糖核酸
病理
RNA剪接
作者
Zemin Li,Han Yin,Kai Chen,Bo Ding,Jingyun Xu,Mulan Ren,Chuan Zhang,Yang Shen
标识
DOI:10.1016/j.ecoenv.2022.114201
摘要
The incidence rate of human uterine leiomyomas is over 70% in the women of childbearing age, which has caused serious health and financial burden. Our previous study confirmed that Bisphenol A (BPA),representative environmental estrogen, promoted the proliferation of human uterine leiomyomas and up-regulated the expression of cell proliferation-related genes. In this study, by combining ChIP-seq and RNA-seq, it was shown that after BPA intervention, H3K27ac modification levels and gene expression levels were altered in uterine leiomyomas cells. Moreover experimental verification found that BPA can regulate ITGA2 through the transcription factor XBP1, activate the downstream PI3K/AKT signaling pathway, eventually promote the proliferation of uterine leiomyomas. The present study provides new insights into the pathogenesis associated with exposure to BPA and other endocrine disruptors with similar effects by defining XBP1 as an important regulator, and which may act as an intervention and treatment target for uterine leiomyomas.
科研通智能强力驱动
Strongly Powered by AbleSci AI