褐色脂肪组织
产热
旁分泌信号
内分泌系统
自分泌信号
内分泌学
脂肪组织
内科学
脂肪因子
FGF21型
白色脂肪组织
瘦素
生物
能量稳态
肌动蛋白
骨骼肌
成纤维细胞生长因子
医学
激素
肥胖
受体
作者
Fabiane Ferreira Martins,Vanessa Souza‐Mello,Márcia Barbosa Águila,Carlos Alberto Mandarim‐de‐Lacerda
出处
期刊:Hormone Molecular Biology and Clinical Investigation
[De Gruyter]
日期:2022-10-26
卷期号:44 (2): 219-227
被引量:8
标识
DOI:10.1515/hmbci-2022-0044
摘要
Abstract Brown adipose tissue (BAT) remains active in adults, oxidizing fatty acids or glucose and releasing energy in the form of heat. Brown adipocytes and enhanced thermogenesis are targets for treating obesity and its comorbidities. BAT shows high synthesis activity and secretes several signaling molecules. The brown adipokines, or batokines, take action in an autocrine, paracrine, and endocrine manner. Batokines have a role in the homeostasis of the cardiovascular system, central nervous system, white adipose tissue, liver, and skeletal muscle and exert beneficial effects on BAT. The systemic function of batokines gives BAT an endocrine organ profile. Besides, the batokines Fibroblast Growth Factor-21, Vascular Endothelial Growth Factor A, Bone Morphogenetic Protein 8, Neuregulin 4, Myostatin, and Interleukin-6 emerge as targets to treat obesity and its comorbidities, deserving attention. This review outlines the role of six emerging batokines on BAT and their cross-talk with other organs, focusing on their physiological significance and diet-induced changes.
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