Enantioselective conjugate addition of malonates to α,β-unsaturated aldehydes catalysed by 4-oxalocrotonate tautomerase

The asymmetric conjugate addition of diethyl malonates to α,β-unsaturated aldehydes catalysed by 4-oxalocrotonate tautomerase was developed and used in the chemoenzymatic synthesis of (+)-femoxetine.