失调
共生
串扰
牙周炎
生物
微生物学
寄主(生物学)
代谢途径
肠道菌群
免疫学
新陈代谢
细菌
医学
生态学
遗传学
生物化学
内科学
物理
光学
作者
Jing Ding,Cheng Zhao,Li Gao
摘要
Abstract The onset and development of periodontitis centers around microbiota dysbiosis and disrupted host responses. Dynamic metabolic activities of the subgingival microbiota modify the polymicrobial community, shape the microenvironment, and modulate the host response. A complicated metabolic network exists in interspecies interactions between periodontal pathobionts and commensals, which can lead to the development of dysbiotic plaque. Dysbiotic subgingival microbiota undergo metabolic interactions with the host and disrupt host–microbe equilibrium. In this review, we discuss the metabolic profiles of the subgingival microbiota, the metabolic crosstalk in polymicrobial communities, including pathobionts and commensals, and the metabolic interactions between microbes and the host.
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