Radical approaches for C(sp3)–N bond cleavage in deaminative transformations

)-N bond cleavage often rely on two-electron ionic pathways or transition metal catalysis, which typically require activated amines or toxic reagents, limiting their broad applicability. In contrast, radical-based approaches provide a promising alternative, utilizing homolytic C-N bond cleavage to generate carbon-centered radicals that can participate in a range of transformations. These methods offer complementary substrate scopes and unique reactivity profiles, expanding the synthetic utility of amines. This review summarizes recent advancements in radical-mediated deaminative transformations, focusing on the mechanisms, substrate compatibility, and emerging applications in synthetic organic chemistry.