Ni( ii )-catalyzed enantioselective α-hydrazination of α-fluoroesters: access to chiral quaternary α-fluorinated α-amino acid derivatives

With C 1 -symmetric imidazolidine-pyrroloimidazolone pyridine as the tridentate ligand and Ni(BF 4 ) 2 ·6H 2 O as the Lewis acid, diverse chiral α-hydrazino-α-fluorinated ester derivatives were obtained in high yields and excellent enantioselectivities.