Multiple masks of a Shigella podophage

In this issue of Structure, Subramanian et al. present the cryo-EM structure of Shigella podophage HRP29, which possesses a T7-like tail complex surrounded by six P22/Sf6-like tailspikes and two unique decoration proteins. These colorful masks of HRP29 record the frequent events of horizontal gene transfer during evolution. In this issue of Structure, Subramanian et al. present the cryo-EM structure of Shigella podophage HRP29, which possesses a T7-like tail complex surrounded by six P22/Sf6-like tailspikes and two unique decoration proteins. These colorful masks of HRP29 record the frequent events of horizontal gene transfer during evolution. Cryo-EM structure of a Shigella podophage reveals a hybrid tail and novel decoration proteinsSubramanian et al.StructureOctober 30, 2023In BriefShigella flexneri is a bacterial pathogen of concern and bacteriophage therapy to combat bacterial infections is gaining importance. To date there is only one high-resolution structure of a bacteriophage infecting S. flexneri known and here Subramanian et al. present the cryo-EM structure of the bacteriophage HRP29. Full-Text PDF