Soft Actuators In article number 2307350, Zhongdong Jiao and co-workers present a universal and programmable re-foldability strategy to integrate multiple origami patterns into a single soft origami actuator. This strategy can selectively activate and deactivate origami creases by variable stiffness fibers, thereby enabling multimode morphing capability. This work represents a significant step forward in the development of multifunctional soft actuators and holds great potential for the advancement of agile and versatile soft robots.