天然产物
药物发现
小分子
环肽
肽
计算生物学
生物信息学
化学
生物
生物化学
作者
S You,Glen McIntyre,Toby Passioura
标识
DOI:10.1080/17460441.2024.2367024
摘要
INTRODUCTION: (i.e. not natural product derived) cyclic peptide ligands to targets of interest. AREAS COVERED: In this review, the authors describe the current clinical landscape for cyclic peptide pharmaceuticals. This article focuses on the discovery approaches that have led to the development of different classes of molecules and how the development of newer technologies, particularly phage and mRNA display, has broadened the clinical applicability of such molecules. EXPERT OPINION: cyclic peptide drug discovery is reaching maturity, with the first drugs identified through display screening approaches reaching the market in recent years. Many more are in clinical trials; however, significant technical challenges remain. Technological improvements will be required over the coming years to facilitate the identification of membrane permeable cyclic peptides capable of oral availability and targeting intracellular proteins.
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