Enhanced glucose sensing via novel Ni-MOF hybrid structures: Advancements for non-enzymatic wearable glucose sensors

Abstract There is an urgent need of perceptive flexible wearable sensors, for the continuous monitoring of the glucose particularly in a non-invasive way, to control the diabetes at early stages, We have conception of developing non-enzymatic glucose sensing for the detection purpose. Recently, nickel- based metal organic framework (Ni-MOF) has gained a significant importance as a sensing material for label-free, non-enzymatic glucose monitoring using electrochemical sensing techniques. This work, presents a novel state of the art hybridstructure of Ni-MOF consisting of stacked nanosheets embedded with porous nanopillars randomly providing large no. of active sites for the glucose detection. The hybrid structure indicate a close contact between the glucose and the active sites of Ni ions ensuring an efficient glucose sensing. As synthesized Ni-MOF was used for the potentiometric and amperometric electrochemical detection of the glucose using screen-printed electrode (SPE) which are suitable for flexible sensor applications. With SPE, Ni-MOF shows a wide detection range for glucose from 60 µM to 600 µM with the LOD of 0.28 µM and the sensitivity of 4462.03 µA mM-1 cm-2, which is extremely favourable for glucose detection in sweat and saliva of human. The as developed material has potential as a working electrode on the flexible substrate like polyethylene terephthalate (PET), for sensing glucose in sweat and saliva samples.