免疫系统
骨免疫学
组织工程
自愈水凝胶
再生(生物学)
干细胞
免疫学
作者
Sara Nadine,Clara R. Correia,João F. Mano
出处
期刊:Biomaterials advances
日期:2022-08-01
卷期号:140: 213058-213058
标识
DOI:10.1016/j.bioadv.2022.213058
摘要
The well-known synergetic interplay between the skeletal and immune systems has changed the design of advanced bone tissue engineering strategies. The immune system is essential during the bone lifetime, with macrophages playing multiple roles in bone healing and biomaterial integration. If in the past, the most valuable aspect of implants was to avoid immune responses of the host, nowadays, it is well-established how important are the crosstalks between immune cells and bone-engineered niches for an efficient regenerative process to occur. For that, it is essential to recapitulate the multiphenotypic cellular environment of bone tissue when designing new approaches. Indeed, the lack of osteoimmunomodulatory knowledge may be the explanation for the poor translation of biomaterials into clinical practice. Thus, smarter hydrogels incorporating immunomodulatory bioactive factors, stem cells, and immune cells are being proposed to develop a new generation of bone tissue engineering strategies. This review highlights the power of immune cells to upgrade the development of innovative engineered strategies, mainly focusing on orthopaedic and dental applications. • Macrophages play fundamental regulatory roles during bone healing. • The immune system determines the success or failure of bone substitute implants. • Advanced immunomodulatory hydrogels have been proposed for bone regeneration.
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