伤害感受器
体感系统
机械感受器
神经科学
电池类型
刺激形态
背根神经节
感觉神经元
感觉
感觉系统
生物
神经元
伤害
细胞
受体
生物化学
遗传学
作者
Edward C. Emery,Patrik Ernfors
出处
期刊:Oxford University Press eBooks
[Oxford University Press]
日期:2018-12-11
卷期号:: 128-155
被引量:23
标识
DOI:10.1093/oxfordhb/9780190860509.013.4
摘要
Abstract Primary sensory neurons of the dorsal root ganglion (DRG) respond and relay sensations that are felt, such as those for touch, pain, temperature, itch, and more. The ability to discriminate between the various types of stimuli is reflected by the existence of specialized DRG neurons tuned to respond to specific stimuli. Because of this, a comprehensive classification of DRG neurons is critical for determining exactly how somatosensation works and for providing insights into cell types involved during chronic pain. This article reviews the recent advances in unbiased classification of molecular types of DRG neurons in the perspective of known functions as well as predicted functions based on gene expression profiles. The data show that sensory neurons are organized in a basal structure of three cold-sensitive neuron types, five mechano-heat sensitive nociceptor types, four A-Low threshold mechanoreceptor types, five itch-mechano-heat–sensitive nociceptor types and a single C–low-threshold mechanoreceptor type with a strong relation between molecular neuron types and functional types. As a general feature, each neuron type displays a unique and predicable response profile; at the same time, most neuron types convey multiple modalities and intensities. Therefore, sensation is likely determined by the summation of ensembles of active primary afferent types. The new classification scheme will be instructive in determining the exact cellular and molecular mechanisms underlying somatosensation, facilitating the development of rational strategies to identify causes for chronic pain.
科研通智能强力驱动
Strongly Powered by AbleSci AI