Study Progress on Thymic Stromal Lymphopoietin

Thymic stromal lymphopoietin(TSLP), identified in 1994, plays an important role in regulating the activation of dendritic cells, the differentiation and maturation of lymphocyte subsets. Up to now, great attention has been paid to TSLP. Evidence shows that TSLP has an pivotal effect on the diffferentiation and maturation of Th2 and regulatory T cells. Moreover, TSLP is related with the pathogenesis of allergic diseases,such as asthma, atopic dermatitis and allergic rhinitis, twrther studies on the mechanism of TSLP are important. Key words: Thymic stromal lymphopoietin;  Dendritic cells;  Allergic inflammation;  Regulatory T Cells