尿素
肌酐
急性肾损伤
透析
肾
血尿素氮
化学
医学
药理学
生物化学
内科学
作者
Di‐Wei Zheng,Pei Pan,Ke-Wei Chen,Jin‐Xuan Fan,Chu‐Xin Li,Han Cheng,Xian‐Zheng Zhang
标识
DOI:10.1038/s41551-020-0582-1
摘要
Patients with kidney failure commonly require dialysis to remove nitrogenous wastes and to reduce burden to the kidney. Here, we show that a bacterial cocktail orally delivered in animals with kidney injury can metabolize blood nitrogenous waste products before they diffuse through the intestinal mucosal barrier. The microbial cocktail consists of three strains of bacteria isolated from faecal microbiota that metabolize urea and creatinine into amino acids, and is encapsulated in calcium alginate microspheres coated with a polydopamine layer that is selectively permeable to small-molecule nitrogenous wastes. In murine models of acute kidney injury and chronic kidney failure, and in porcine kidney failure models, the encapsulated microbial cocktail significantly reduced urea and creatinine concentrations in blood, and did not lead to any adverse effects.
科研通智能强力驱动
Strongly Powered by AbleSci AI