Ultrathin surface coated water-soluble cobalt ferrite nanoparticles with high magnetic heating efficiency and rapid in vivo clearance

Abstract To obtain magnetic nanoparticles with high magnetic heating efficiency and rapid in vivo clearance, this study utilized an improved linear response theory model to theoretically simulate the specific absorption rate (SAR) value versus the particle size of cobalt ferrite nanoparticles (CFNPs). An accurate SAR curve consistent with experimental results was obtained using cubes instead of spheres as the shape of CFNPs, given that cube was closer to the actual shape of prepared CFNPs. Under the guidance of simulation, we predicted and prepared water-soluble cubic CFNPs of 10–13 nm in size, with an ultrathin surface coating less than 1 nm in thickness. These CFNPs were experimentally verified to have high magnetic heating efficiency and rapid in vivo clearance rate. Our CFNPs of 11.8 nm in size had a high intrinsic loss power of 12.11 nHm2/kg. Most of the cells were killed within 30 min under magnetic heating with CFNPs. In an in vivo study, these CFNPs can heat a tumor area to 45 °C (ΔT > 9 °C) within 120 s under a weak alternating magnetic field (27 kA/m, 115 kHz). Notably, these CFNPs had significant tumor inhibition rate in vivo and can be cleared from the body by more than 64% within 2 weeks, demonstrating excellent rapid in vivo clearance. This result was close to the clearance level of the magnetic resonance imaging contrast agent Feridex. Therefore, our CFNPs had high magnetic heating efficiency and rapid in vivo clearance rate, indicating their great potential for future clinical applications.