不育
精子
遗传学
无精子症
女性不育
体外受精
生育率
基因
作者
Jing Dai,Tianlei Zhang,Jing Guo,Qinwei Zhou,Gu Yifan,Jue Zhang,Liang Hu,Yurong Zong,Juan Song,Shuoping Zhang,Can Dai,Fei Gong,Guangxiu Lu,Wei Zheng,Ge Lin
标识
DOI:10.1016/j.ajhg.2021.02.004
摘要
Summary Total fertilization failure (TFF) can occur during in vitro fertilization (IVF) treatments, even following intracytoplasmic sperm injection (ICSI). Various male or female factors could contribute to TFF. Increasing evidence suggested that genetic variations in PLCZ1, which encodes 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase zeta-1 (PLCζ), is involved in oocyte activation and is a key male factor in TFF. In the present study, we explored the genetic variants in male individuals that led to TFF. A total of 54 couples with TFF or poor fertilization (fertilization rate
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