Ultrasensitive luteolin electrochemical sensor based on zeolitic imidazolate frameworks-derived cobalt trioxide @ nitrogen doped carbon nanotube/amino-functionalized graphene quantum dots composites modified glass carbon electrode

The accurate determination of luteolin is of great significance for food and pharmaceutical industry. Herein, an ultrasensitive electrochemical sensor for luteolin based on zeolitic imidazolate frameworks (ZIF)-derived cobalt trioxide @ nitrogen doped carbon nanotube/amino-functionalized graphene quantum dots composites modified glass carbon electrode (Co3O4@N-CNTs/NH2-GQDs/GCE) was constructed. The Co3O4@N-CNTs composites were synthesized through direct pyrolysis of ZIF-67 in the N2 atmosphere, which exhibited outstanding electrochemical performance for luteolin due to the conductivity of N-CNTs and the catalytic action of Co3O4. Under optimized conditions, the Co3O4@N-CNTs /NH2-GQDs/GCE exhibited a linear range of 0.5–1000 nM for detecting luteolin, with a low detection limit (LOD) of 0.1 nM (S/N = 3). Furthermore, the sensor was successfully applied for the detection of luteolin in Chrysanthemum extracts.