Solubility, solvation thermodynamics and solvent effect of thiabendazole in several cosolvent blends

Abstract Equilibrium solubility determination and model correlation were performed in the present research for the systems formed by solid solute of thiabendazole and binary aqueous blends of acetonitrile, methanol, n-propanol and isopropanol. Experiments at temperatures ranging from 283.15 to 323.15 K were conducted by the use of the shake-flask saturation technique at 101.2 kPa. For the given binary solvent blends, the minimum mole fraction solubility was recorded in water at 283.15 K; and the maximum one, in neat organic solvent at 323.15 K. The generated equilibrium solubility was satisfactorily described by two models, modified van’t Hoff-Jouyban–Acree and Jouyban–Acree, with the relative average deviations (%) of no more than 6.08. Good prediction results of extend Hildebrand solubility approach (relative average deviations  (2) in ethyl acetate (1)  + ethanol (2) solutions with ethyl acetate-rich compositions, and by water (2) solvent in aqueous blends with rich water compositions.