化学
利巴韦林
核苷
酶
化学合成
核苷类似物
立体化学
生物化学
体外
基因型
基因
作者
Martin J. Slater,C. Gowrie,G. G. Freeman,Steven A. Short
标识
DOI:10.1016/s0960-894x(96)00514-8
摘要
2′-Deoxy-2′-fluoro-ribavirin has been efficiently synthesised from 2′-deoxy-2′-fluorouridine using nucleoside transferase as the key step, and evaluated for its antiviral properties in cell culture. An efficient synthesis of 3,5-di-O-p-chlorobenzoyl-2-deoxy-2-fluoro-β-D-ribofuranose is also described.
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