多不饱和脂肪酸
一氧化氮
氧化应激
神经保护
活力测定
脂多糖
活性氧
过氧化物酶体增殖物激活受体
化学
药理学
细胞培养
受体
体内
生物化学
细胞
内科学
内分泌学
生物
脂肪酸
医学
生物技术
遗传学
作者
Lorenzo Corsi,Bendj Edith Momo Dongmo,Rossella Avallone
标识
DOI:10.3109/09637486.2014.986073
摘要
Many reports have shown promising beneficial effects of long-chain polyunsaturated fatty acids (L-PUFAs) of the omega 3 series in several brain diseases. In the present study, we tested the hypothesis that omega 3 fatty acids supplement reduced pro-inflammatory functions in vitro and in vivo. We demonstrated that a supplement rich in PUFAs (SRP) increased cell viability in a dose-dependent manner suggesting its protective role against lipopolysaccharide (LPS)-induced cell death in BV2 microglial cell line. In the same cultures, the supplement rich in PUFAs reduced the reactive oxygen species (ROS) and nitric oxide (NO) production. A most prominent target for ROS management is the family of peroxisome proliferator-activated receptors (PPARs). The co-treatment with SRP and LPS increased significantly the nuclear immunoreactivity of PPAR-γwhen compared the LPS treatment alone. Moreover, the chronic administration of the SRP in rats, increased the immunoreactivity of the PPAR-γ1 protein confirming its potential neuroprotective effect.
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